Enterovirus-Echovirus 11 Infection – the European Region Situation at a glance

Since the Disease Outbreak News published on 31 May 2023 which reported enterovirus, Echovirus 11 (E-11) infection in France, additional Member States in the European Region have notified WHO of cases of E-11 among newborns.

As of 26 June 2023, Croatia, Italy, Spain, Sweden, and the United Kingdom of Great Britain and Northern Ireland have reported cases of E-11 infection confirmed in newborns. Further investigations and public health responses are being implemented in each of these Member States.

This Disease Outbreak News provides updates on the event and the public health response implemented in the reporting and non-reporting countries in the European Region.

Based on the limited information available, WHO assesses the public health risk for the general population to be low, while we continue to encourage countries to monitor for and report on cases. Health facilities caring for newborns should familiarize themselves with the signs and symptoms of echovirus and maintain vigilance for potential healthcare-associated infections and outbreaks.

Description of the cases

On 5 May 2023, France reported an increase in cases of severe neonatal sepsis associated with Enterovirus (Echovirus-11 (E-11)). A total of nine cases of neonatal sepsis with hepatic impairment and multi-organ failure with seven deaths were reported between July 2022 and April 2023 from four hospitals in three regions of France.

As of 26 June 2023, Croatia reported one confirmed case of E-11 infection from a cluster of enterovirus diseases in neonates detected in June 2023, Italy has reported seven cases of E-11 infection confirmed in neonates between April and June 2023, Spain reported two cases of E-11 infection in 2023, Sweden reported five E-11 cases with four cases of meningoencephalitis among infants due to E-11 infection between 2022 and 15 June 2023, and the United Kingdom of Great Britain and Northern Ireland (the UK) reported two cases in March 2023.

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