Standing recommendations for mpox issued by the Director-General of the World Health Organization (WHO) in accordance with the International Health Regulations (2005) (IHR)

Throughout the multi-country outbreak of mpox spanning July 2022 to May 2023, which was determined by the WHO DG to constitute a public health emergency of international concern (PHEIC) under the International Health Regulations (2005) (IHR), countries’ response efforts were guided by temporary recommendations issued by the Director-General, taking into account the advice of an Emergency Committee.

While mpox continues to pose a public health risk among certain populations after termination of the PHEIC in May 2023, and since WHO recommends the control and elimination of human-to-human transmission as appropriate, countries’ preparedness and response actions can now be guided by the standing recommendations issued by the WHO Director-General under the IHR.

There is a need for longer-term attention and support to address this emerging disease, with robust, proactive and sustainable mpox control and elimination of human-to-human transmission, particularly where mpox continues to occur regularly, to stop outbreaks and prevent resurgence of global spread. WHO is preparing a Global Strategic framework for enhancing control and achieving elimination of human-to-human transmission of mpox (2023-2027) which is undergoing a consultative process with WHO Member States, partners and stakeholders.