Paediatric Pancreatic Cancer: Signs and Risk Factors To Watch Out For

Pancreatic cancer is rare to begin with, and rarer in childhood. Physicians may tend to miss a timely diagnosis for pediatric cases. Pancreatic cancer, across all ages, ranks 24^th in incidence in India, but 18^th in mortality. It is a rare site but one of the leading mortality sites in cancer patients.

The prognosis, based on the type of tumour and its potential to metastasize, is often poor because the disease remains asymptomatic in its early stages. By the time signs develop, the cancer has usually advanced locally or is metastatic. The poor long-term outcome of pancreatic cancer in both adults and children is even more reason for us to reinforce the steps to prevent it, ideally in childhood. Pancreatic tumors can form when cells in the pancreas begin to grow uncontrollably and form a mass or lump.

Pancreatic tumours are different in childhood from adulthood and tend to have better treatment outcomes. An early diagnosis and management of tumours which may be potentially malignant (insulinoma, gastrinoma etc.) or are primarily malignant (pancreatoblastoma) are critical to increase survival rates.

We know from genetic studies that certain gene mutations and family history (of pancreatic cancer) may lead to a predisposition towards pancreatic cancer in childhood. Diabetes Type 1 at an early age is considered as a risk for pancreatic cancer. High exposure to toxic pesticides such as benzene and toluene, too, have been known to increase the risk of pediatric pancreatic cancer.

Childhood provides a window for doctors to initiate preventative management by identifying, assessing and where possible, treating predispositions towards pancreatic malignancy. Certain predispositions such as genetic mutations or child-obesity (especially, high BMI in children between 7 and 13 years of age) which may be diagnosed at an early age, and some childhood diseases, such as pediatric cancers and diabetes Type 1 and 2, which may trigger pancreatic cancer in adulthood, should be closely monitored by doctors to prevent adult incidence of the disease.

If pancreatic tumours don’t secrete hormones, then it is difficult to diagnose early. But secretions from malignant tumours create signs which aid in diagnosis. Some perceptible signs of pediatric pancreatic cancer are: –

• Unexplained weight loss or gain, and chronic fatigue, but given their nature, may get misdiagnosed first, causing delays in treatment.
• Low blood sugar or low sodium level, leading to blurred vision, muscle weakness, headaches, dizziness, profuse sweating, unabated hunger, confusion.
• Reflux in the food pipe.
• Chronic/watery diarrhea, gastrointestinal bleeding, nausea, and vomiting.
• Appetite loss.
• Palpable lump in the abdomen.
• Recurrent stomach ulcers.
• Constantly feeling thirsty, passing less urine, dry skin, and dry mouth.
• High blood pressure.
• Purple stretch marks.
• Jaundice if a tumor in the pancreas blocks the bile duct, leading to a bilirubin build-

Pediatricians should consider the possibility of pediatric pancreatic cancer during the follow-up of children who have experienced idiopathic acute pancreatitis or cholestatic hepatitis in the past. Many of the signs of pediatric pancreatic cancer can be mistaken for other diseases and should be investigated with imaging and histopathological exams, especially the risk groups.

Diagnosing pediatric pancreatic cancer can be challenging, as it is a relatively rare type of cancer in children. It can be diagnosed through CT scan, ultrasound, MRI, blood tests, endoscopy and biopsy.

Pancreatoblastoma is the most common neoplasm in children with the disease. Treatment of any kind of pediatric pancreatic cancer will depend on the nature of the malignancy, its site, and the stage of metastasis. Surgery such as a Whipple procedure, chemotherapy, and targeted therapy (mTOR inhibitor therapy) are the primary ways to treat it. A pediatric oncologist would be the specialist who would head the team of other pediatric health personnel to draw up a treatment plan. Given the rarity of the incidence, participating in a clinical trial could also be considered.

Palliative care comprising pain management, symptomatic relief, and emotional and psychological support for the child and family may be necessary to ensure the pediatric patient’s quality of life is maintained as much as possible.

Extensive screenings strategies for monitoring risk-prone children need an effort from both families and the medical community. Children with hereditary diseases associated with pancreatic cancer or with family-occurrences of such conditions should be regularly screened for pancreatic cancer. Screening the pediatric population for diabetes mellitus and obesity will not just help prevent pediatric pancreatic cancer, but also the later onset of pancreatic cancer in adulthood.

 

By: Dr. Sanketh Kotne, Consultant Medical Oncologist, HCG Cancer Centre Vizag