The Esthetic Clinics® Publishes 20-Year Review of 22 Studies Covering 9,000+ Patients: Tranexamic Acid, Widely Used for Menstrual Bleeding, Shows Promise in Facial Aesthetic Surgery

~ A new meta-analysis highlights TXA’s efficacy in reducing blood loss, surgical time, swelling, and bruising across multiple facial cosmetic procedures.

Mumbai, 20th June 2025 — The Esthetic Clinics (TEC®️), one of India’s leading multi-speciality centres for cosmetic and reconstructive surgery, dermatology, and aesthetic medicine, has spearheaded a landmark systematic review and meta-analysis published in the Journal of Plastic, Reconstructive & Aesthetic Surgery (Impact Factor: 2.5), the official journal of the British Association of Plastic, Reconstructive and Aesthetic Surgeons (BAPRAS). The study spotlights Tranexamic Acid (TXA) as a game-changing adjunct in facial aesthetic surgery, consolidating data from 22 high-quality studies with data from over 9,000 patients across a 20-year span, making it the most comprehensive review of TXA’s role in aesthetic surgery to date.

Originally used in trauma care and orthopaedic surgeries — and more widely known for treating heavy menstrual bleeding — TXA has now shown significant promise in enhancing outcomes in facial cosmetic procedures such as rhinoplasty, rhytidectomy (facelift), and blepharoplasty (eyelid surgery). The study revealed that TXA administration — whether intravenous, topical, oral, or through local infiltration — consistently resulted in:

• Reduced intraoperative blood loss

• Shorter surgical duration

• Lower postoperative swelling (oedema)

• Decreased bruising (ecchymosis)

• Reduced drain output

Importantly, these benefits were achieved without an increase in adverse events, reaffirming TXA’s safety profile even across different delivery methods and patient populations.

“This review elevates Tranexamic Acid from a supplementary option to a strong candidate for standard use in facial aesthetic surgery,” said Dr. Debraj Shome, senior author of the study and Director at The Esthetic Clinics®. “With consistent, high-quality evidence from over 9,000 patients across 22 studies, TXA demonstrates clear clinical value. While final treatment decisions must always be patient- and context-specific, these findings provide a compelling case for its broader consideration in surgical protocols worldwide.”

The study further highlights the synergistic benefits of combining TXA with local anaesthetic agents such as lidocaine and epinephrine. This combination was found to not only enhance hemostasis and reduce operative time but also prolong the duration of local anaesthesia.

While results were promising across all included studies, the authors have called for standardised dosing regimens and outcome grading systems to support consistent and safe implementation globally. The review also outlines key areas for future research, including long-term safety data and optimal administration strategies.

This milestone study is expected to influence global surgical guidelines and elevate postoperative care standards in aesthetic practices.

About The Esthetic Clinics (TEC®️)

The Esthetic Clinics® is one of India’s leading multi-speciality centres for cosmetic and reconstructive surgery, dermatology, and aesthetic medicine. Established in 2009, the clinic network operates across Mumbai, New Delhi, Hyderabad, and Kolkata, offering evidence-based treatments in both advanced stand-alone facilities and leading hospital environments. With a multidisciplinary approach, the clinics integrate surgical precision with dermatological science to address aesthetic concerns as well as complex reconstructive conditions.

The group was co-founded by Dr. Debraj Shome, a globally recognised facial plastic surgeon and the first and only surgeon from Asia certified by the American Board of Facial Cosmetic Surgery. He is also a Fellow of the American Academy of Cosmetic Surgery (FAACS) and the American College of Surgeons (FACS), with advanced training from the University of Utah and MD Anderson Cancer Center, USA. His pioneering work in oculoplastic surgery, oncology-related facial reconstruction, and aesthetic innovation has shaped the clinic’s research-led culture. Dr. Rinky Kapoor, co-founder and internationally trained dermatologist with credentials from Singapore’s National Skin Centre and Stanford University, brings deep expertise in cosmetic dermatology and dermato-surgery.

Under their leadership, The Esthetic Clinics® has earned global recognition, ranked among the Top 10 Cosmetic Clinics in the World by The Luxe Insider (2023) and consistently featured among Mumbai’s best in the Times Health Survey (2019–2022). The institution is also actively engaged in clinical research, with multiple patents and peer-reviewed publications in leading international medical journals.